An international collaboration led by Prof Daniel Krappmann (Helmholtz Zentrum München) reported in Nature Communications the identification of the DUB Otulin as a regulator of the levels of nutrient transporters on the cell surface. This insight is important for potential treatments of metabolic diseases.
Stangl et al. (2019). Regulation of the endosomal SNX27-retromer by OTULIN. Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex
This research is the result of close international cooperation between Helmholtz Zentrum München and scientists at the Medical Research Council (MRC) in Cambridge (UK), the University of Oxford (UK), UbiQ in Amsterdam (Netherlands) and the Walter and Eliza Hall Institute (WEHI) in Melbourne (Australia).
Regulation of the endosomal SNX27-retromer by OTULIN
Aurelia Stangl, Paul R. Elliott, Adan Pinto-Fernandez, Sarah Bonham, Luke Harrison, Annalisa Schaub, Kerstin Kutzner, Kirstin Keusekotten, Paul T. Pfluger, Farid El Oualid, Benedikt M. Kessler, David Komander & Daniel Krappmann
Stangl et al. (2019). Regulation of the endosomal SNX27-retromer by OTULIN.