what do we do

ubiquitin research tools

enabling drug discovery in the ubiquitin field since 2010

Access to well-defined and advanced ubiquitin research tools and ubiquitin-like research tools is of paramount importance for drug development, fundamental research and structural studies. Since we founded our company in 2010, our ubiquitin and ubiquitin-like) research tools have been well-recognized by both Pharma and Academia. Many leading laboratories in the field worldwide use our innovative and custom reagents. We also collaborate with outstanding scientists on research projects to further our insights in this growing field. We are proud that our joint efforts regularly result in publications in high-ranking journals. You can find examples in the "recent publications" section below this page. For an extensive reference list of our publications since 2010, please visit our download center.

Please explore how our ubiquitin research tools expedite the three stages of early drug discovery, i.e. target - lead - lead on target, by clicking on the buttons below:

target

Identify and validate your target using UbiQ Probes.

lead

Screen your compounds targeting DUBs and Ubl proteases using UbiQ Assay reagents.  

lead on target

Our reagents enable you in lead on target validation and lead optimization.

target

Identify and validate your target using UbiQ Probes.

lead

Screen your compounds targeting DUBs and Ubl proteases using UbiQ Assay reagents.  

lead on target

Our reagents enable you in lead on target validation and lead optimization.

about our products

ubiquitin research tools: reagents

In our laboratory at the Amsterdam Science Park, UbiQ develops, manufactures, and commercializes research tools such as ubiquitinated peptides, activity-based probes, and activity assay reagents. In addition to ubiquitin, we also make ubiquitin-like variants (SUMO, ISG15, NEDD8, etc.) of our reagents.

It is important to note that all our research tools are “For laboratory research use only, not for use in animals and humans".

about our services

ubiquitin research tools: custom made reagents

With our UbiQ technologies we can synthesize site-selective ubiquitinated peptides and reagents that are not available through biological approaches. Next to our catalogue reagents, we offer a tailored and chemical approach to producing specific ubiquitinated conjugates. This custom ubiquitin synthesis approach allows researchers to design ubiquitin conjugates that are not readily available through biological methods.

news

our blog

Reagents for your SARS-CoV-2 research

  Reagents for your SARS-CoV-2 research  The SARS-CoV-2 coronavirus encodes a papain-like cysteine protease PLpro (NSP3) that cleaves the viral polyprotein, removes ubiquitin-like ISG15 protein modifications and (with lower activity) Lys48-linked polyubiquitin chains. As PLPro is essential for SARS-CoV-2 replication, it represents a promising target for the...

where to meet us

recent publications

Collaborative research between the University of York, University of Glasgow and UbiQ looks into the (essential) roles of ubiquitin proteases (DUBs) and ubiquitin conjugation in Leishmania parasites.

21st Royal Society of Chemistry - Medicinal Chemistry Symposium, 13 - 15 September 2021, Cambridge UK. Poster title: A ubiquitin activating enzyme as a novel therapeutic target for leishmaniasis. Daniel Harris (1), Dr Mads Gabrielson (2), Dr...

Discover the many possibilities with our tools​

UbiQ remains committed to advancing the ubiquitin research landscape through our state-of-the-art reagents and innovative chemical approaches. Our dedication to collaboration and research excellence ensures we remain at the forefront of this dynamic field. Reach out to us by filling out our contact form.