activity based probe for SUMO proteases
UbiQ-156 is an activity based probe for SUMO proteases. It is based on the human SUMO2 sequence (C48S) in which the C-terminus is functionalized with the electrophilic vinyl methyl ester (VME) group. The N-terminus is labeled with biotin*.
* an aminohexanoic acid (Ahx) linker creates extra space for efficient access of biotin binding entities.
Mendes et al. Biochim Biophys Acta – Mol Cell Res 2016, 1863, 139