Ac-ISG15prox-VPS

a potent, irreversible and specific activity-based probe for ISG15 proteases

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350.00

Description

UbiQ-262 is a potent, irreversible and specific activity-based probe for ISG15 proteases. It is prepared by total chemical synthesis and based on the proximal part of mouse ISG15 (aa 77-155). To improve stability, Cys77 and Cys144 are replaced by Ser. It contains a C-terminal vinyl pentynyl sulfone (VPS) electrophile which allows for post-labeling modification of cross-linked [UbiQ-237]::[ISG15 protease] complexes by using click chemistry with for example biotin-azide.