H2A(5-21) K13 Ub

an H2A(5-21) polypeptide which is modified with ubiquitin at K13 via a native isopeptide bond

productsheet

code UbiQ-172 Category
product UbiQ-172 Category

Additional information

Weight 0.05 kg
Applications

, , , ,

target

,

source

human sequence, synthetic

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purity

storage

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

aliquot size

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250.00

Description

UbiQ-172 is an H2A(5-21) polypeptide which is modified with ubiquitin at K13 via a native isopeptide bond. It can be used as a substrate for ubiquitin proteases, to investigate the mechanism of binding and recognition by proteins that contain ubiquitin-associated domains or ubiquitin-interacting motifs (UIMs) and as an antigen for immunizations. This product has been synthesized by chemical ligation.

Additional information

Weight 0.05 kg
Applications

, , , ,

target

,

source

human sequence, synthetic

shipping

purity

storage

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

aliquot size

El Oualid, F., et al. Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin. Angewandte Chemie Int. Ed. 49, 10149-10153 (2010).
http://www.ncbi.nlm.nih.gov/pubmed/21117055

Faesen, A.C., et al. The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types. Chem. Biol. 18, 1550-1561 (2011).
http://www.ncbi.nlm.nih.gov/pubmed/22195557

Dikic, I., et al. Ubiquitin-binding domains – from structures to functions. Nat. Rev. Mol. Cell. Biol. 10, 659-671 (2010).
http://www.ncbi.nlm.nih.gov/pubmed/19773779

Licchesi, J.D., et al. An ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nat. Struct. Mol. Biol. 19, 62-71 (2012).
http://www.ncbi.nlm.nih.gov/pubmed/22157957