Biotin-Ahx-SUMO2-VME

a potent, irreversible and specific activity-based probe for SUMO proteases, labeled with biotin on the N-terminus

productsheet

code UbiQ-156 Category Tags , ,
product UbiQ-156 Category Tags , ,

Additional information

Weight 0.05 kg
catalogue

Custom Aliquot size

wholesale

Applications

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target

,

source

shipping

purity

molecular weight

storage

upon arrival, powder at −20°C; solution at −80°C.

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

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240.00

Description

UbiQ-156 is an activity-based probe for SUMO proteases. It is based on the human SUMO2 sequence (C48S) in which the C-terminal is equipped with the electrophilic vinyl methyl ester (VME) group. The N-terminus is labeled with biotin and an aminohexanoic acid (Ahx) linker is used to create extra space between the biotin and SUMO2 protein for efficient access of biotin binding entities. It has been prepared by total chemical synthesis and is therefore well-defined in terms of biotinylation site.

Additional information

Weight 0.05 kg
catalogue

Custom Aliquot size

wholesale

Applications

, , , , , ,

target

,

source

shipping

purity

molecular weight

storage

upon arrival, powder at −20°C; solution at −80°C.

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

Albrow et al. Chem Biol 2011, 18, 722.
https://www.ncbi.nlm.nih.gov/pubmed/21700208

Mendes et al. Biochim Biophys Acta – Mol Cell Res 2016, 1863, 139.
https://www.ncbi.nlm.nih.gov/pubmed/26522917