Ub-VS

a potent and specific inhibitor of deubiquitinating enzymes (DUBs)

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Weight 0.005 kg
aliquot size

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Description

Ubiquitin-Viny Sulfone (UbiQ-108) is a potent and specific inhibitor of deubiquitinating enzymes (DUBs). This activity probe can be used for activity profiling experiments and determining DUB inhibitor specificity. It targets all two of the major DUB families: USP and OTU.

Additional information

Weight 0.005 kg
aliquot size

Applications

, , , ,

target

source

shipping

purity

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

Galardy, P., et al. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. Methods in Enzymology. 399, 120-131 (2005).
http://www.ncbi.nlm.nih.gov/pubmed/16338352

de Jong, A., et al. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. ChemBiochem 13, 2251-2258 (2012).
http://www.ncbi.nlm.nih.gov/pubmed/23011887

Wrigley, J.D. et al. Enzymatic characterisation of USP7 deubiquitinating activity and inhibition. Cell Biochem. Biophys. 60, 99-111 (2011)
http://www.ncbi.nlm.nih.gov/pubmed/21468692