K48 linked di-ubiquitin

a native K48 linked di-ubiquitin

code UbiQ-033 Category
product UbiQ-033 Category

Additional information

Weight 0.05 kg
aliquot size

bulk

,

Applications

,

target

source

shipping

purity

molecular weight

storage

Powder at −20°C; solution at −80°C. Please avoid multiple freeze/thaw cycles.

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

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Description

UbiQ-033 is native K48 linked di-ubiquitin which can be used as a substrate for proteases that cleave the isopeptide linkage between two ubiquitin proteins. It can also be used to investigate mechanism of binding and recognition by proteins that contain ubiquitin-associated domains or ubiquitin-interacting motifs (UIMs). This product is formed by chemical ligation.

Additional information

Weight 0.05 kg
aliquot size

bulk

,

Applications

,

target

source

shipping

purity

molecular weight

storage

Powder at −20°C; solution at −80°C. Please avoid multiple freeze/thaw cycles.

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

Faesen, A.C., et al. The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types. Chem. Biol. 18, 1550-1561 (2011).
http://www.ncbi.nlm.nih.gov/pubmed/22195557

Licchesi, J.D., et al. An ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nat. Struct. Mol. Biol. 19, 62-71 (2012).
http://www.ncbi.nlm.nih.gov/pubmed/22157957

Walczak, H., et al. Generation and physiological roles of linear ubiquitin chains. BMC Biol. DOI:10.1186/1741-7007-10-23 (2012).
http://www.ncbi.nlm.nih.gov/pubmed/22420778

Keusekotten, K., et al. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell 153, 1312-1326 (2013).
http://www.ncbi.nlm.nih.gov/pubmed/23746843

Rivkin, E., et al. The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature 498, 318-324 (2013).
http://www.ncbi.nlm.nih.gov/pubmed/23708998