K11 linked di-ubiquitin

a native K11 linked di-ubiquitin

code UbiQ-014 Category
product UbiQ-014 Category

Additional information

Weight 0.025 kg
catalogue size

Applications

,

target

source

human sequence, synthetic

shipping

purity

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

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Description

UbiQ-014 is native K11 linked di-ubiquitin which can be used as a substrate for proteases that cleave the isopeptide linkage between two ubiquitin proteins. It can also be used to investigate mechanism of binding and recognition by proteins that contain ubiquitin-associated domains or ubiquitin-interacting motifs (UIMs). This product is formed by chemical ligation.

Additional information

Weight 0.025 kg
catalogue size

Applications

,

target

source

human sequence, synthetic

shipping

purity

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

El Oualid, F., et al. Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin. Angewandte Chemie Int. Ed. 49, 10149-10153 (2010). http://www.ncbi.nlm.nih.gov/pubmed/21117055

Faesen, A.C., et al. The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types. Chem. Biol. 18, 1550-1561 (2011). http://www.ncbi.nlm.nih.gov/pubmed/22195557

Dikic, I., et al. Ubiquitin-binding domains – from structures to functions. Nat. Rev. Mol. Cell. Biol. 10, 659-671 (2010). http://www.ncbi.nlm.nih.gov/pubmed/19773779

Licchesi, J.D., et al. An ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nat. Struct. Mol. Biol. 19, 62-71 (2012). http://www.ncbi.nlm.nih.gov/pubmed/22157957