Ub-VME

a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs)

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Description

UbiQ-005 is a potent, irreversible and specific inhibitor of deubiquitinating enzymes (DUBs). It inhibits the hydrolysis of poly-ubiquitin chains on substrate proteins in vitro and thus enhances poly-Ub chain accumulation. UbiQ-005 functions as an activity based DUB probe and can also be used for structural biology studies of DUB-Ub complexes

Galardy, P., et al. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: crystallography, activity profiling, and protease identification. Methods in Enzymology. 399, 120-131 (2005). http://www.ncbi.nlm.nih.gov/pubmed/16338352

de Jong, A., et al. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. ChemBiochem 13, 2251-2258 (2012).
http://www.ncbi.nlm.nih.gov/pubmed/23011887