blogs
First Poster Prize award at the EMBO ubiquitin conference in Cavtat.
alfred nijkerk2024-10-08T11:01:05+02:00We congratulate Dr Jason Collins from the National Institute of Dental and Craniofacial Research / NIH, Bethesda, USA with the First Poster Prize award at the EMBO ubiquitin conference in Cavtat.
Poster Prize awardees at the Biochemical Society conference in Edinburgh.
alfred nijkerk2023-06-27T12:13:19+02:00We congratulate the Poster Prize awardees at last week's Deubiquitylases and Ubl-proteases conference of the Biochemical Society in Edinburgh!
Moving our offices & laboratories.
alfred nijkerk2023-02-23T14:19:05+01:00We are happy and proud to announce that we have moved our office and labs to a brand new building at Science Park 301, just a five minutes walk from our old laboratories in the...
Launch of an activity-based probe designed to selectively target USP7.
alfred nijkerk2023-01-16T13:38:13+01:00We hereby announce the launch of an activity-based probe that is designed to selectively target USP7: K58K(biotin) cRh110-Cys-Ubv(USP7)-PA (UbiQ-314). UbiQ-314 is based on Ub with the following mutations: T7D, L8Y, I13R, E34L, Q40N, L69A, and L71A....
Public-private partnership grant awarded by Health-Holland: Towards new drug therapies by a better understanding of ubiquitin metalloprotease activity.
alfred nijkerk2022-08-26T16:33:02+02:00We are happy to announce that UbiQ and Prof Titia Sixma (Netherlands Cancer Institute, Oncode Institute) were recently awarded a new public-private partnership grant by Health-Holland, which is part of the Dutch Life Sciences &...
Reagents for your SARS-CoV-2 research
alfred nijkerk2022-08-22T14:04:53+02:00Reagents for your SARS-CoV-2 research The SARS-CoV-2 coronavirus encodes a papain-like cysteine protease PLpro (NSP3) that cleaves the viral polyprotein, removes ubiquitin-like ISG15 protein modifications and (with lower activity) Lys48-linked polyubiquitin chains. As PLPro is essential for SARS-CoV-2 replication, it represents a promising target for the...
In memoriam: Professor Huib Ovaa
alfred nijkerk2021-06-01T14:50:42+02:00On the 19th of May 2020, our co-founder and dear friend Professor Dr. Huib Ovaa passed away from prostate cancer at the age of 46 years. In the past year, Huib has undergone a variety...
where to meet us
International Plant Proteostasis Conference 2024
alfred nijkerk2024-07-19T14:19:56+02:00September 17 - 20, 2024 Vienna, Austria International Plant Proteostasis Conference 2024 Contact: Farid El Oualid (CSO) (sponsorship)
EMBO conference on Ubiquitin 2024
alfred nijkerk2024-04-11T12:24:51+02:00September 27 - October 1, 2024 Cavtat, Croatia Ubiquitin and ubiquitin-like proteins in health and disease. Contact: Alfred Nijkerk (CEO)
2nd Severo Ochoa Conference: Ligating the Ubiquitin Family; Physiology, Disease, and Future Directions June 2024
alfred nijkerk2024-04-11T12:32:52+02:00June 24 - 25, 2024 Bilbao, Spain 2nd Severo Ochoa Conference: Ligating the Ubiquitin Family; Physiology, Disease, and Future Directions June 2024 Contact: Farid El Oualid (CSO) (sponsorship)
Ubiquitin & Friends Symposium May 2024
alfred nijkerk2024-04-11T12:36:16+02:00May 2 - 3, 2024 Vienna, Austria Ubiquitin & Friends Symposium May 2024 Contact: Farid El Oualid (CSO) (sponsorship)
BIO-Europe Spring 2024
alfred nijkerk2024-02-06T11:22:35+01:00UbiQ will attend BIO-Europe Spring. March 17 - 20, 2024 Barcelona, Spain Contact: Alfred Nijkerk BIO-Europe: https://informaconnect.com/bioeurope-spring/
Biochemical Society: Deubiquitylases and Ubl-proteases, from fundamental principles to therapeutic opportunities 2023
alfred nijkerk2023-03-10T14:55:56+01:00June 19 - 21, 2023 Edinburgh, UK Deubiquitylases and Ubl-proteases: from fundamental principles to therapeutic opportunities 2023. Contact: Farid El Oualid (CSO)
Ubiquitin & Friends Symposium April 2023
alfred nijkerk2023-06-13T10:20:25+02:00April 27 - 28, 2023 Vienna, Austria Ubiquitin & Friends Symposium April 2023 Contact: Farid El Oualid (CSO) (sponsorship)
publications
Characterization of the Ubiquitin and ISG15 Deconjugase Activity of SARS-CoV-1 and SARS-CoV-2 Papain-Like Protease.
alfred nijkerk2023-03-22T21:29:26+01:00UbiQ is proud to have contributed a chapter to the Methods in Molecular Biology book series (MIMB,volume 2591), together with the Department of Biochemistry & Structural Biology, University of Texas Health Science Center at San...
Catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6.
alfred nijkerk2022-09-06T15:40:05+02:00UbiQ is proud to have been part of a major collaborative research project focused on studying the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 and whose results have been reported recently in Nature Communications. Yuan et al. Crystal...
Collaborative research between the University of York, University of Glasgow and UbiQ looks into the (essential) roles of ubiquitin proteases (DUBs) and ubiquitin conjugation in Leishmania parasites.
alfred nijkerk2022-08-24T11:47:41+02:0021st Royal Society of Chemistry - Medicinal Chemistry Symposium, 13 - 15 September 2021, Cambridge UK. Poster title: A ubiquitin activating enzyme as a novel therapeutic target for leishmaniasis. Daniel Harris (1), Dr Mads Gabrielson (2), Dr...
Anti–COVID-19 Drug Design by targeting a molecular scissor of Ubiquitin and ISG15.
alfred nijkerk2022-02-24T10:48:14+01:00UbiQ is proud to have been part of a major collaboration reported recently by Rut et al. in Science Advances, describing the activity profiling and crystal structures of inhibitor bound SARS-CoV-2 PLpro: Activity profiling and crystal...
Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex.
alfred nijkerk2021-06-01T11:16:24+02:00Collaborative research between the University of York, University of Glasgow and UbiQ looks into the (essential) roles of ubiquitin proteases (DUBs) and ubiquitin conjugation in Leishmania parasites. Leishmaniasis is a neglected tropical disease caused by parasites...
Strategy for Development of Site-Specific Ubiquitin Antibodies.
alfred nijkerk2021-06-01T11:12:15+02:00As part of collaborative research between The Netherlands Cancer Institute, Leiden University Medical Centre, UbiQ and the University of Amsterdam, van Kruijsbergen et al. report in Frontiers in Chemistry detailed protocols for the development of...
Diubiquitin-Based NMR Analysis: Interactions Between Lys6-Linked diUb and UBA Domain of UBXN1.
alfred nijkerk2021-06-01T11:13:02+02:00As part of collaborative research carried out by The Netherlands Cancer Institute, Leiden University Medical Centre, Utrecht University, UbiQ and the University of Cologne, Hameed et al. report in Frontiers in Chemistry the synthesis of...