our blog
14 July 2025
Poster prize award at the GRK2243 Symposium Understanding Ubiquitylation
alfred nijkerk2025-08-30T13:11:20+02:00We congratulate Dr Cara Ellison from the University of Oxford with the Poster Prize award at the GRK2243 Symposium Understanding Ubiquitylation: From Molecular Mechanisms to Disease 2025, in Würzburg (Germany).
16 May 2025
Live cell delivery of ubiquitin reagents by bead loading
alfred nijkerk2025-08-30T13:11:40+02:00We present a new protocol for intracellular delivery of our reagents (Figure 1). In protocol P010, (also in our resource download center), we outline a...
8 October 2024
First Poster Prize award at the EMBO ubiquitin conference
alfred nijkerk2025-08-30T13:09:28+02:00We congratulate Dr Jason Collins from the National Institute of Dental and Craniofacial Research / NIH (Bethesda, USA) with the First Poster Prize award at the 2024 EMBO ubiquitin conference in Cavtat.
27 June 2023
Poster Prize awardees at the Biochemical Society conference in Edinburgh
alfred nijkerk2025-08-30T13:17:25+02:00We congratulate the Poster Prize awardees at last week's Deubiquitylases and Ubl-proteases conference of the Biochemical Society in Edinburgh!
3 March 2023
Launch of four new activity-based probes for deubiquitinating enzymes
alfred nijkerk2025-08-30T13:21:22+02:00We present four new HA-tagged activity-based probes for deubiquitinating enzymes (DUBs). The HA peptide sequence (YPYDVPDYA) allows for the sensitive identification or purification of DUBs by anti-HA antibodies and/or anti-HA-agarose. The HA tag is separated from...
21 February 2023
Moving our offices & laboratories.
alfred nijkerk2025-08-30T13:23:35+02:00We are happy and proud to announce that we have moved our office and labs to a brand new building at Science Park 301, just a five minutes walk from our old laboratories in the...
2 September 2022
Introducing UbiQ-314: an activity-based probe designed to selectively target USP7
alfred nijkerk2025-08-30T14:07:15+02:00We announce the launch of an activity-based probe that is designed to selectively target USP7: UbiQ-314. Reported by Gjonaj et al. (Chem Comm 2019, 55, 5075), probe UbiQ-314 is based on Ub...
where to meet us
14 July 2025
Australian Ubiquitin Summit 2025
alfred nijkerk2025-08-30T13:12:14+02:00November 20 - 23, 2025 in Lorne, Australia
Lorne Ubiquitin - The Australia Ubiquitin Summit, 2025
Contact: Farid El Oualid (CSO, attending the conference) and Alfred Nijkerk (CEO, sponsorship)
28 March 2025
Innovation For Health 2025
alfred nijkerk2025-08-30T13:11:49+02:00April 3, 2025, Rotterdam, the Netherlands
Innovation For Health 2025
Contact: Alfred Nijkerk (CEO)
24 January 2025
Symposium Understanding Ubiquitylation
alfred nijkerk2025-08-30T13:12:58+02:00June 2 - 4, 2025, Würzburg, Germany
GRK2243 Symposium Understanding Ubiquitylation: From Molecular Mechanisms to Disease, 2025
Contact: Farid El Oualid (CSO) and Alfred Nijkerk (CEO) (sponsorship)
19 July 2024
International Plant Proteostasis Conference
alfred nijkerk2025-08-30T13:13:25+02:00September 17 - 20, 2024, Vienna, Austria
International Plant Proteostasis Conference 2024
Contact: Farid El Oualid (CSO) (sponsorship)
11 April 2024
EMBO conference on Ubiquitin
alfred nijkerk2025-08-30T13:14:19+02:00September 27 - October 1, 2024 Cavtat, Croatia
Ubiquitin and ubiquitin-like proteins in health and disease.
Contact: Alfred Nijkerk (CEO)
8 February 2024
2nd Severo Ochoa Conference
alfred nijkerk2025-08-30T13:14:59+02:00June 24 - 25, 2024 Bilbao, Spain
2nd Severo Ochoa Conference: Ligating the Ubiquitin Family; Physiology, Disease, and Future Directions June 2024
Contact: Farid El Oualid (CSO) (sponsorship)
6 February 2024
Ubiquitin & Friends Symposium
alfred nijkerk2025-08-30T13:15:13+02:00May 2 - 3, 2024 Vienna, Austria
Ubiquitin & Friends Symposium May 2024
Contact: Farid El Oualid (CSO) (sponsorship)
our publications
1 August 2025
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism
alfred nijkerk2025-08-30T13:10:52+02:00UbiQ is proud to have contributed to this paper in Nature Communications (2025, 16, article 6991), describing our scientific adventures with USP1 and PCNA. If you are interested in DNA damage response,...
16 January 2023
Characterization of the Ubiquitin and ISG15 Deconjugase Activity of SARS-CoV-1 and SARS-CoV-2 Papain-Like Protease
alfred nijkerk2025-08-30T13:37:59+02:00UbiQ is proud to have contributed a chapter to the Methods in Molecular Biology book series (MIMB,volume 2591), together with scientists at the University of Texas Health...
23 August 2022
Catalytic and regulatory mechanisms of the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6
alfred nijkerk2025-08-30T14:15:42+02:00UbiQ is proud to have been part of a major collaborative research project focused on studying the dual-specificity ubiquitin/FAT10 E1 enzyme Uba6 and whose results have been published in Nature Communications 2022,...
29 March 2022
Collaborative research looks into the (essential) roles of ubiquitin proteases and ubiquitin conjugation in Leishmania parasites
alfred nijkerk2025-08-30T14:21:18+02:00Poster presentation by Daniel Harris at the 21st Royal Society of Chemistry - Medicinal Chemistry Symposium (13 - 15 September 2021, Cambridge UK).
Title: A ubiquitin activating enzyme as a novel therapeutic target for leishmaniasis.
Daniel Harris...
18 November 2020
Anti–COVID-19 Drug Design by targeting a molecular scissor of Ubiquitin and ISG15
alfred nijkerk2025-08-30T15:26:52+02:00UbiQ is proud to have been part of a major collaboration reported recently by Rut et al. in Science Advances (2020, 6, eabd4596) describing the activity profiling and crystal structures of inhibitor...
9 July 2020
Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex
alfred nijkerk2025-08-30T15:49:30+02:00We are proud to present collaborative research (Burge et al. PLoS Pathogens 2020, 16: e1008784), between the University of York, University of Glasgow and UbiQ that describes the (essential) roles of ubiquitin...
21 February 2020