target identification and validation

UbiQ can assist your target discovery in the UPS with our wide range of activity-based probes.

 

applications

• structural studies
• phenotypic protein profiling on cell lysates for target validation
• chemical proteomics for target identification (i.e., pull down, purification, western blotting, MS)

 

targets

• E1-E2-E3 enzymes – with our UbiQ activity-based Triple E probes
• all major DUB families (UCH, USP, and OTU) and Ubl proteases – with our activity-based DUB probes
• proteasome – with our activity-based probe UbiQ-018

 

services

• custom development of advanced reagents, e.g. with substrate context

 

experience

• UbiQ has developed more than 15 custom probes for a range of customers
• numerous DUBs (e.g. USP4, UCH-L5 and a viral ovarian tumor DUB) have been successfully crystallised with our activity-based probes
• target validation and identification of DUBs, E1 and E2 enzymes in infectious diseases (University Glasgow, University of York, GSK)

> See UbiQ-Probes fact sheets for more information, available options, and references. Also available in Japanese