UbiQ is proud to have contributed to this paper in Nature Communications.

Nat Commun 16, 6991 (2025). https://doi.org/10.1038/s41467-025-61768-0
USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA.
Niels Keijzer, Jan Sakoltchik, Kaustav Majumder, Nina van Lil, Farid El Oualid, Alexander Fish & Titia K. Sixma
https://www.nature.com/articles/s41467-025-61768-0

For all those interested in DNA damage response, DUBs, advanced tool development, and cryo-EM:
Please have a look at the LinkedIn post of our collaborator and NKI scientist Niels Keijzer about our scientific adventures with USP1 and PCNA.