![UbiQ-054](https://ubiqbio.com/wp-content/uploads/2015/11/UbiQ-054.png)
Biotin-Ahx-Ub-VME
a potent, irreversible and specific inhibitor of deubiquitylating enzymes (DUBs), labeled on the N-terminus with biotin
Additional information
Weight | 0.005 kg |
---|---|
aliquot size | |
bulk | |
Applications | Crystallization, Pull down, Purification, Western Blot, Phenotypic protein profiling |
target | |
source | |
shipping | |
purity | |
molecular weight | |
storage | Powder at −20°C, solution at −80°C. Please avoid multiple freeze/thaw cycles. |
sample preparation | For detailed sample preparation see product sheet. |
regulatory statement |
€250.00
- Description
- Additional information
- references
Description
UbiQ-054 (Biotin-Ahx-Ub-VME) is a potent, irreversible and specific inhibitor of deubiquitylating enzymes, which is labeled on the N-terminus with biotin. An aminohexanoic acid linker is used to create extra space between the biotin and Ub protein for efficient access of biotin binding entities.
Additional information
Weight | 0.005 kg |
---|---|
aliquot size | |
bulk | |
Applications | Crystallization, Pull down, Purification, Western Blot, Phenotypic protein profiling |
target | |
source | |
shipping | |
purity | |
molecular weight | |
storage | Powder at −20°C, solution at −80°C. Please avoid multiple freeze/thaw cycles. |
sample preparation | For detailed sample preparation see product sheet. |
regulatory statement |
Misaghi, S., et al. Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate. J. Biol. Chem. 280, 1512-1520 (2005).
http://www.ncbi.nlm.nih.gov/pubmed/15531586
de Jong, A., et al. Ubiquitin-based probes prepared by total synthesis to profile the activity of deubiquitinating enzymes. ChemBiochem 13, 2251-2258 (2012).
http://www.ncbi.nlm.nih.gov/pubmed/23011887