Me4BodipyFL-Ahx3Leu3VS

a fluorescent proteasome activity-based probe that can be used for accurate profiling of proteasome activity in cell lysates, intact cells, and murine and human patient-derived material

productsheet

code UbiQ-018 Category Tag
product UbiQ-018 Category Tag

Additional information

Weight 0.05 kg
aliquot size

Applications

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source

shipping

purity

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.
regulatory statement

€380.00

Description

Me4BodipyFL-Ahx3Leu3VS (UbiQ-018) is a fluorescent proteasome activity-based probe that can be used for accurate profiling of proteasome activity in cell lysates, intact cells, and murine and human patient-derived material, with high sensitivity using SDS-PAGE. The probe allows for direct scanning of the gel for fluorescent emission of the distinct proteasome subunits and circumvents the use of western-blot analysis. Due to its suitable biochemical and biophysical properties the fluorescent probe can also be used for confocal laser scanning microscopy and flow cytometry-based experiments.

Additional information

Weight 0.05 kg
aliquot size

Applications

, ,

target

source

shipping

purity

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.
regulatory statement

  1. UbiQ protocol P006: Fluorescence-based proteasome activity profiling
  2. Berkers et al. Profiling proteasome activity in tissue with fluorescent probes. Mol Pharm 2007, 739, 739: http://www.ncbi.nlm.nih.gov/pubmed/17708652
  3. Berkers et al. Probing the specificity and activity profiles of the proteasome inhibitors bortezomib and delanzomib. Mol Pharm 2012, 9, 1126: http://www.ncbi.nlm.nih.gov/pubmed/22432738