K29 linked di-ubiquitin

isopeptide K29 linked di-ubiquitin

productsheet

code UbiQ-016 Category
product UbiQ-016 Category

Additional information

Weight 0.025 kg
aliquot size

,

Applications

, , ,

target

source

shipping

purity

molecular weight

storage

Powder at −20°C; solution at −80°C. Please avoid multiple freeze/thaw cycles.
sample preparation

For detailed sample preparation see product sheet.
regulatory statement

€210.00

Description

UbiQ-016 is native K29 linked di-ubiquitin which can be used as a substrate for proteases that cleave the isopeptide linkage between two ubiquitin proteins. It can also be used to investigate mechanism of binding and recognition by proteins that contain ubiquitin-associated domains or ubiquitin-interacting motifs (UIMs). This product is formed by chemical ligation.

Additional information

Weight 0.025 kg
aliquot size

,

Applications

, , ,

target

source

shipping

purity

molecular weight

storage

Powder at −20°C; solution at −80°C. Please avoid multiple freeze/thaw cycles.
sample preparation

For detailed sample preparation see product sheet.
regulatory statement

  1. El Oualid et al. Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin. Angewandte Chemie Int Ed 2010, 49, 10149: http://www.ncbi.nlm.nih.gov/pubmed/21117055
  2. Faesen et al. The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types. Chem Biol 2011, 18, 1550: http://www.ncbi.nlm.nih.gov/pubmed/22195557
  3. Dikic et al. Ubiquitin-binding domains – from structures to functions. Nat Rev Mol Cell Biol 2010, 10, 659: http://www.ncbi.nlm.nih.gov/pubmed/19773779
  4. Licchesi et al. An ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nat Struct Mol Biol 2012, 19, 62: http://www.ncbi.nlm.nih.gov/pubmed/22157957