K11 linked di-ubiquitin

isopeptide K11 linked di-ubiquitin

productsheet

code UbiQ-014 Category
product UbiQ-014 Category

Additional information

Weight 0.025 kg
Applications

, , ,

target

source

human sequence, synthetic
shipping

purity

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.
regulatory statement

aliquot size

€210.00

Description

UbiQ-014 is native K11 linked di-ubiquitin which can be used as a substrate for proteases that cleave the isopeptide linkage between two ubiquitin proteins. It can also be used to investigate mechanism of binding and recognition by proteins that contain ubiquitin-associated domains or ubiquitin-interacting motifs (UIMs). This product is formed by chemical ligation.

Additional information

Weight 0.025 kg
Applications

, , ,

target

source

human sequence, synthetic
shipping

purity

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.
regulatory statement

aliquot size

  1. El Oualid et al. Chemical Synthesis of Ubiquitin, Ubiquitin-Based Probes, and Diubiquitin. Angewandte Chemie Int Ed 2010, 49, 10149: http://www.ncbi.nlm.nih.gov/pubmed/21117055
  2. Faesen et al. The Differential Modulation of USP Activity by Internal Regulatory Domains, Interactors and Eight Ubiquitin Chain Types. Chem Biol 2011, 18, 1550: http://www.ncbi.nlm.nih.gov/pubmed/22195557
  3. Dikic et al. Ubiquitin-binding domains – from structures to functions. Nat Rev Mol Cell Biol 2010, 10, 659: http://www.ncbi.nlm.nih.gov/pubmed/19773779
  4. Licchesi et al. An ankyrin-repeat ubiquitin-binding domain determines TRABID’s specificity for atypical ubiquitin chains. Nat Struct Mol Biol 2012, 19, 62: http://www.ncbi.nlm.nih.gov/pubmed/22157957