Description

UbiQ’s Anti-Ubiquitinated Histone H2B (z-152107) antibody is available through our partner Ximbio.

C-terminus monoubiquitination of histone H2B acts as a signal for downstream processes such as gene regulation, genome packaging, histone modification crosstalk, and DNA repair. How the ubiquitination levels are controlled and how the Ub signal is translated to downstream effects is poorly understood. An antibody that detects K123 monoubiquitinated yeast H2B, homologue to human H2B K120, will enable research to discover the fundamental principles of the regulation and function of monoubiquitination of H2B. The antibody is developed using an ubiquitin-polypeptide antigen based on the amino-acids 115-130 of the yeast H2B protein, linked by a proteolytically stable bond.

Immunogen: Ub-polypeptide antigen based on amino acids 115 – 130 of yeast H2B

Reactivity: Human, Saccharomyces pombe and Saccharomyces cerevisiae

To order, or for more details on this antibody please refer to:
the scientific reference: http://dx.doi.org/10.7554/eLife.18919
the product website: Anti-Ubiquitinated Histone H2B (Lys123)
or alternatively by contacting enquiries@ximbio.com

For more information about Ximbio please refer to the website of www.ximbio.com

Additional information

Van Welsem et al. Nucl Acid Res 2018, 46, 11251.
https://www.ncbi.nlm.nih.gov/pubmed/30203048