custom ubiquitinated peptides

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Our UbiQ-PEP service provides monoubiquitinated peptides with a range of modifications to meet your research needs. Peptides are site-selectively monoubiquitinated via a native isopeptide link using our Ub ligation technology. These can then be used for:
  1. epitope mapping (e.g. with deubiquitinating enzymes)
  2. protein structure-function analysis
  3. pull-down experiments
  4. structural biology
 
Specifications and available options
  • peptide length
up to 20 amino acids
 
  • ubiquitinated lysine
site-selectively monoubiquitinated via a native isopeptide link
 
  • standard delivery time
4 to 8 weeks
 
  • purity
>90% by LC-MS and/or SDS-PAGE
 
  • N-terminal modifications
acetyl, biotin, dye (e.g. TAMRA, 5-carboxyRh110)
 
please contact us discuss your project and/or receive a detailed quote.
 
literature: (1) El Oualid et al. Angew Chem Int Ed. 2010, 49, 10149. (2) F. El Oualid & H. Ovaa. “Thiolysine and selenolysine building blocks and their use in site- and chemoselective modification of peptides and proteins. 2009. U.S. Patent U58729009. PCT/NL2010/050277, US61/176,616, EP09160430.6