custom ubiquitin conjugate synthesis
We offer a tailored and chemical approach to producing specific ubiquitinated conjugates. This custom ubiquitin synthesis approach allows researchers to design ubiquitin conjugates that are not readily available by biological methods. Custom ubiquitin synthesis als can play a crucial role in creating specific probes that can be used to dissect the ubiquitination process itself, providing deeper insights into enzyme-subjugate interactions that are critical for developing targeted therapies. Besides their application as advanced assay reagents (for high-throughput screening) and specific probes, ubiquitin conjugates are also of great value as antigens for antibody development.
Explore the forefront of ubiquitin research and drug discovery with UbiQ’s innovative reagents – discover more today
Our total synthesis based technology platform allows us to prepare ubiquitin and ubiquitin like protein reagents with various modifications:
features
assay reagents, probes, chains and ubiquitinated peptides
ubiquitin and ubiquitin-like proteins e.g. Nedd8, SUMO, ISG15 etc
electrophiles (warheads), peptides (substrate context), tags, unnatural amino acids
price & timelines
prices are on a project basis and bulk preparation (starting at 2 mg)
- 6 – 8 weeks lead time for most projects
references
over the years, we have developed a large number of custom probes, assay reagents and ubiquitinated peptides for the top 10 Pharma, biotechs and academic institutions: DUB specific assay reagents probes, HTRF assays, custom electrophiles, assays reagents and probes with substrate context.
we also co-developed an antibody for yeast K123 Ub-H2B.
want to know more?
Please contact us at sales@ubiqbio.com to discuss your project and/or receive a detailed quote.
literature
- Peptide pull-down assays with monoubiquitinated H2B & PTEN based peptides: R. Kessler et al. “dDsk2 regulates H2Bub1 and RNA polymerase II pausing at dHP1c complex target genes“. Nat. Commun. 2015, 6, article number 7049. Doi: 10.1038/ncomms8049
connect with us
We encourage you to leave your details through our online form to fully harness the potential of custom ubiquitin synthesis for your research and development projects. Engage with our team to explore how our custom reagents service can advance your studies in molecular biology and drug discovery.