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targeting the ubiquitin system
  • latest news

    • 2015, February 26
      Ubiquitin Research and Drug Discovery co...
      UbiQ will be present with an exhibition stand at the Ubiquitin Research and D... read more »
    • 2015, February 20
      Mechanism of UCH-L5 Activation and Inhib...
      Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in R... read more »
    • 2015, February 08
      SLAS 2015 conference
      UbiQ will be present at the SLAS 2015 meeting in Washington on 7- 11 February... read more »

  • UbiQ-Probes

    Activity-based probes for deubiquitylases (DUBs) are based on ubiquitin with a C-terminal warhead designed to react with the active site cysteine residue present in most DUBs and potentially an N-terminal detection tag. The warhead serves an electrophile and reacts with the nucleophilic active site cysteine residue that is present in most DUBs. Our warheads: vinylmethyl ester (VME) propargylamide (PA) vinyl sulfone (VS) N-terminal detection tags: TAMRA Cy5 biotin HA DUB probes can be used for X-ray studies of DUB-Ub complexes or to ... read more »