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targeting the ubiquitin system
  • latest news

    • 2015, February 26
      Ubiquitin Research and Drug Discovery co...
      UbiQ will be present with an exhibition stand at the Ubiquitin Research and D... read more »
    • 2015, February 08
      SLAS 2015 conference
      UbiQ will be present at the SLAS 2015 meeting in Washington on 7- 11 February... read more »
    • 2014, December 11
      UbiQ News - di-ubiquitin VME probes intr...
      Our latest newsletter: http://eepurl.com/7nWlX.  In this editio... read more »

  • UbiQ-Probes

    Activity-based DUB probes are based on the Ub sequence, a reactive C-terminal warhead and potentially an N-terminal detection tag. The warhead serves an electrophile and reacts with the nucleophilic active site cysteine residue that is present in most DUBs. DUB probes can be used for X-ray studies of DUB-Ub complexes or to visualize the activity of multiple DUBs in a single experiment. This way they have proved indispensable in the search for novel DUBs. Please see the probes reagents webshop for all our currently available synthetic DUB activity probes.   ... read more »