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targeting the ubiquitin system
  • latest news

    • 2014, December 11
      UbiQ News - di-ubiquitin VME probes intr...
      Our latest newsletter: http://eepurl.com/7nWlX.  In this editio... read more »
    • 2014, October 18
      UbiQ is attending the EMBO conference in...
      The EMBO conference: 'Ubiquitin & ubiquitin-like proteins: At the cro... read more »
    • 2014, October 06
      Avacta announces anti-diUbiquitin affime...
      Avacta announces the first anti-diUbiquitin affimers for the linkages K48 K33... read more »

  • UbiQ-Probes

    Activity-based DUB probes are based on the Ub sequence, a reactive C-terminal warhead and potentially an N-terminal detection tag. The warhead serves an electrophile and reacts with the nucleophilic active site cysteine residue that is present in most DUBs. DUB probes can be used for X-ray studies of DUB-Ub complexes or to visualize the activity of multiple DUBs in a single experiment. This way they have proved indispensable in the search for novel DUBs. Please see the probes reagents webshop for all our currently available synthetic DUB activity probes.   ... read more »