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targeting the ubiquitin system
  • latest news

    • 2014, May 09
      Avacta Announce Collaboration with UbiQ ...
      First of a series of new Affimer reagents which opens up an important market ... read more »
    • 2014, March 13
      UbiQ-Assay HTS programs
      UbiQ-Assay reagents have been used in various HTS campaigns over the years. R... read more »
    • 2013, July 03
      Publication in Cell on OTU DUBs
      Using ubiquitin chains of all linkage types, it was revealed that most human ... read more »

  • UbiQ-Chains

    Ubiquitin modification regulates most aspects of cell life. Both the type and number of poly-ubiquitin chains, conjugated to a protein target, regulate distinct signals that affect physiological processes. Poly-ubiquitin chains are built by forming an isopeptide bond between the C-terminus of one ubiquitin and one of the seven potential lysines (K6, K11, K27, K29, K33, K48 or K63) of the preceding ubiquitin. All these chain types have been identified in cells and as such access to them is important for studying their biological roles and mode of action. [1]    Wi... read more »