Ub photoLeu8

a crosslinking reagent based on ubiquitin in which Leu8 is replaced by the photoreactive analog photoleucine (photoLeu)

productsheet

code UbiQ-153 Category Tags ,
product UbiQ-153 Category Tags ,

Additional information

Weight 0.1 kg
aliquot size

bulk size

Applications

, , ,

target

, ,

source

shipping

purity

>95%

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

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250.00

Description

UbiQ-153 is a crosslinking reagent based on ubiquitin in which Leu8 is replaced by the photoreactive analog photoleucine (photoLeu). Upon irradiation of the diazirine with UV light, a very reactive carbene species is formed. Unspecific binding is minimal for carbene based crosslinking because carbenes are quenched quickly by water, meaning only residues that are very nearby (and thereby contribute to tight binding) will react covalently.

Additional information

Weight 0.1 kg
aliquot size

bulk size

Applications

, , ,

target

, ,

source

shipping

purity

>95%

molecular weight

storage

sample preparation

For detailed sample preparation see product sheet.

regulatory statement

(1) Chojnacki et al. Cell Chem Biol 2017, 24, 443.
https://www.ncbi.nlm.nih.gov/pubmed/28330605

(2) Liang et al. Angew Chem Int Ed 2017, 56, 2744.

(3) Zhou et al. Nat Comm 2016, 7, article 10589.

(4) Dubinsky et al. Bioorg Med Chem 2012, 20, 554.